Maralixibat chloride
Livmarli (maralixibat chloride) is a small molecule pharmaceutical. Maralixibat chloride was first approved as Livmarli on 2021-09-29. It is used to treat pruritus in the USA. It has been approved in Europe to treat alagille syndrome. It is known to target ileal sodium/bile acid cotransporter.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| livmarli | New Drug Application | 2024-07-29 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MARALIXIBAT CHLORIDE, LIVMARLI, MIRUM | |||
| 2030-03-13 | ODE-429 | ||
| 2028-09-29 | ODE-379 | ||
| 2026-09-29 | NCE | ||
| 2026-03-13 | NPP | ||
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Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 6 | 1 | — | — | 7 |
| Cholestasis | D002779 | HP_0001396 | K83.1 | — | 3 | 2 | — | — | 5 |
| Intrahepatic cholestasis | D002780 | — | — | — | 2 | 1 | — | — | 3 |
| Pruritus | D011537 | HP_0000989 | L29 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 6 | — | — | 1 | 7 |
| Alagille syndrome | D016738 | EFO_0004151 | Q44.71 | — | 6 | — | — | 1 | 7 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | — | — | — | 2 |
| Fibrosis | D005355 | — | — | — | 2 | — | — | — | 2 |
| Biliary liver cirrhosis | D008105 | — | K74.3 | — | 2 | — | — | — | 2 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | — | 1 | — | — | — | 1 |
| Biliary atresia | D001656 | EFO_0004217 | Q44.2 | — | 1 | — | — | — | 1 |
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | — | 1 | — | — | — | 1 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overweight | D050177 | — | E66.3 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Maralixibat chloride |
| INN | maralixibat chloride |
| Description | Maralixibat chloride, sold under the brand name Livmarli, is a medication used to treat cholestatic pruritus in people with Alagille syndrome. Maralixibat chloride is an ileal bile acid transporter (IBAT) inhibitor.
|
| Classification | Small molecule |
| Drug class | ileal bile acid transporter (IBAT) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3ccc(C[N+]45CCN(CC4)CC5)cc3)cc2)[C@H]1O.[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 228113-66-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17879 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB16226 |
| UNII ID | V78M04F0XC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC10A2
SLC10A2
Organism
Homo sapiens
Gene name
SLC10A2
Gene synonyms
ASBT, ISBT, NTCP2
NCBI Gene ID
Protein name
ileal sodium/bile acid cotransporter
Protein synonyms
Apical sodium-dependent bile acid transporter, ASBT, IBAT, ileal apical sodium-dependent bile acid transporter, ileal bile acid transporter, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, ISBT, Na(+)-dependent ileal bile acid transporter, Na+/taurocholate cotransporting polypeptide 2, Sodium/taurocholate cotransporting polypeptide, ileal, solute carrier family 10 (sodium/bile acid cotransporter family), member 2, solute carrier family 10 (sodium/bile acid cotransporter), member 2, Solute carrier family 10 member 2
Uniprot ID
Mouse ortholog
Slc10a2 (20494)
ileal sodium/bile acid cotransporter (Q925U7)
Variants
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Livmarli – Mirum Pharmaceuticals
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Safety
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546 adverse events reported
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